What is Ctsb gene?
CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include Keratolytic Winter Erythema and Acute Pancreatitis. Among its related pathways are Innate Immune System and Apoptosis and Autophagy.
Where is cathepsin b located?
H Cathepsin B-Activated Prodrugs Cathepsin B is a cysteine protease that is primarily found in the lysosomes of normal cells, but it is secreted or associated with the plasma membrane of many transformed cells [43].
What does cathepsin G do?
Cathepsin G has many functions. It can clear pathogens, regulate inflammation by modifying the chemokines, cytokines, cell surface receptors,(11-14) and C components,(1) control the blood pressure, and induce thrombogenesis.
What is cathepsin S activity?
Abstract. Cathepsin S (CTSS) is a lysosomal protease whose activity regulation is important for MHC-II signaling and subsequent activation of CD4 + T cell mediated immune responses.
What does cathepsin B cleave?
Cathepsin B is a cysteine protease that acts as an exopeptidase at pH5.5 [3]. Its cleavage specificity prefers, but is not restricted to, basic amino acids at the P1 position and hydrophobic or arginine residues at the P2 position [24].
What does neutrophil elastase do?
Neutrophil elastase is secreted by neutrophils during inflammation, and destroys bacteria and host tissue. It also localizes to neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases.
What is the Elane gene?
The ELANE gene provides instructions for making a protein called neutrophil elastase. This protein is found in neutrophils, a type of white blood cell that plays a role in inflammation and in fighting infection. When the body starts an immune response to fight an infection, neutrophils release neutrophil elastase.
What does cathepsin K do?
Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption. The enzyme’s ability to catabolize elastin, collagen, and gelatin allows it to break down bone and cartilage.
Is neutrophil elastase good?
Clinical significance. Neutrophil elastase is an important protease enzyme that when expressed aberrantly can cause emphysema or emphysematous changes. This involves breakdown of the lung structure and increased airspaces.
What does neutrophil elastase do to the lungs?
Neutrophil elastase inhibitors Neutrophil elastase (NE), a neutral serine protease, is a major constituent of lung elastolytic activity. In addition it potently stimulates mucus secretion and induces CXCL8 release from epithelial cells and may therefore perpetuate the inflammatory state.
What is ctctsb protein used for?
- CTSB protein functions as a necessary modulator of hypertrophic response by regulating TNF-alpha/ASK1/JNK signaling pathway involved in cardiac remodeling. Abeta oligomers, but not fibrils, induce IL-1beta production in primary microglia in a cathepsin B- and reactive oxygen species -dependent manner.
What is cathepsin B (CTSB)?
- Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020] CTSB (Cathepsin B) is a Protein Coding gene.
What is the pathophysiology of CTSB disease?
- Diseases associated with CTSB include Keratolytic Winter Erythema and Annular Erythema . Among its related pathways are A-beta Plaque Formation and APP Metabolism and Activated TLR4 signalling . Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity .
Is there an active enhancer element for CTSB in tandem duplications?
- {ECO:0000269 PubMed:28457472}. Note=The gene represented in this entry is involved in disease pathogenesis. Tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB result in CTSB abnormal expression with pathological consequences.
